Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
| ▸ | DRD3 | P35462 | 1/20 | 0.65 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.55 |
| ▸ | MGLL | Q99685 | 5/20 | 0.51 |
| ▸ | ACACB | O00763 | 2/20 | 0.51 |
| ▸ | ACACA | Q13085 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969942 | 0.92 | MAP3K12 (0.60) | DRD2DRD4DRD3MAP3K12ACACB | |
| SCHEMBL6974760 | 0.86 | MAP3K12 (0.55) | DRD2DRD4DRD3MAP3K12ACACB | |
| SCHEMBL6973351 | 0.85 | DRD2 (0.52) | DRD2DRD4DRD3MAP3K12MGLL | |
| SCHEMBL1387890 | 0.79 | DRD4 (1.00) | DRD2DRD4DRD3MEN1KMT2A | |
| SCHEMBL6975639 | 0.78 | MAP3K12 (0.49) | DRD2DRD4DRD3MAP3K12ACACB | |
| SCHEMBL6969338 | 0.76 | MGLL (0.48) | MAP3K12MGLLMEN1KMT2AMAPT | |
| SCHEMBL6981223 | 0.75 | ACHE (0.55) | MAP3K12MGLLACACBACACAMEN1 | |
| SCHEMBL6976878 | 0.74 | HSD11B1 (0.51) | MAP3K12MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL21284441 | 0.73 | TRPC6 (0.61) | MGLLMEN1KMT2AMAPT | |
| SCHEMBL29911271 | 0.73 | TRPC6 (0.61) | MGLLMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |