Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | VCP | P55072 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14439828 | 0.87 | TDP1 (0.40) | TDP1KMT2ASLC5A2VCP | |
| SCHEMBL6968197 | 0.85 | P2RX3 (0.36) | TDP1P2RX3KMT2ARCE1CYP2C8 | |
| SCHEMBL6962617 | 0.85 | P2RX3 (0.35) | P2RX3CYP2C8 | |
| SCHEMBL6974828 | 0.84 | TDP1 (0.38) | TDP1P2RX3KMT2ASLC5A2ADAMTS5 | |
| SCHEMBL6967282 | 0.83 | TDP1 (0.32) | TDP1KMT2AVCP | |
| SCHEMBL27412267 | 0.83 | TDP1 (0.36) | TDP1P2RX3KMT2ARCE1SLC5A2 | |
| SCHEMBL6972460 | 0.82 | P2RX3 (0.36) | TDP1P2RX3VCP | |
| SCHEMBL5853114 | 0.82 | TDP1 (0.37) | TDP1SLC5A2VCP | |
| SCHEMBL6966496 | 0.82 | VCP (0.37) | TDP1SLC5A2ADAMTS5MMP2MMP13 | |
| SCHEMBL6965896 | 0.81 | VCP (0.36) | TDP1SLC5A2ADAMTS5MMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |