Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINH1 | P50454 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.34 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65457 | 0.90 | CACNA2D1 (0.37) | LMNAMAPK1HTTIDO1TDO2 | |
| SCHEMBL15577528 | 0.83 | HTR2A (0.41) | ALDH1A1LMNAMAPTMAPK1TDP1 | |
| SCHEMBL6963246 | 0.82 | SERPINH1 (0.39) | SERPINH1MAOBALDH1A1LMNAMAPT | |
| SCHEMBL23960436 | 0.79 | CYP19A1 (0.46) | MAOBCACNA1BCNR2CACNA2D1CACNB1 | |
| SCHEMBL27595772 | 0.76 | LMNA (0.35) | ALDH1A1LMNAMAPK1HTTTDP1 | |
| SCHEMBL27966124 | 0.75 | DPP4 (0.41) | IDO1TDO2GABBR2GABBR1 | |
| SCHEMBL3136328 | 0.74 | GABBR2 (0.43) | HTTIDO1TDO2GABBR2GABBR1 | |
| SCHEMBL15577609 | 0.74 | MAPK1 (0.40) | ALDH1A1LMNAMAPTMAPK1HTT | |
| SCHEMBL4440419 | 0.73 | NFE2L2 (0.46) | ALDH1A1MAPTTDP1 | |
| SCHEMBL8497939 | 0.73 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339694-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002040453-A1 | SUBSTITUTED 2-PHENYLAMINOIMIDAZOLINE PHENYL KETONE DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-05-23 | — | — | WO | disclosed |