Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.52 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8720463 | 0.90 | TBXA2R (0.53) | RAB9ARXFP1TBXA2RHRH1ALDH1A1 | |
| SCHEMBL6964102 | 0.85 | KDM4E (0.56) | RAB9AALDH1A1KDM4EKMT2ATSHR | |
| SCHEMBL6971107 | 0.85 | TBXA2R (0.60) | TBXA2RHRH1ALDH1A1KDM4EKMT2A | |
| Oxalic Acid SCHEMBL6970867 | 0.82 | KDM4E (0.47) | RAB9AHRH1ALDH1A1KDM4EKMT2A | |
| SCHEMBL7463247 | 0.79 | ALDH1A1 (0.51) | RAB9ARXFP1ALDH1A1KDM4EKMT2A | |
| Oxalic Acid SCHEMBL6965830 | 0.77 | KDM4E (0.42) | ALDH1A1KDM4EKMT2ATSHRHSD17B10 | |
| SCHEMBL8717428 | 0.77 | TBXA2R (0.60) | TBXA2RHRH1TSHRLTA4HHSD17B10 | |
| Hydrochloric Acid SCHEMBL7609379 | 0.77 | TBXA2R (0.59) | TBXA2RHRH1ALDH1A1LTA4H | |
| SCHEMBL19154143 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2ATSHRLTA4H | |
| SCHEMBL8720453 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EKMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934313-B1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2003-05-14 | — | — | EP | disclosed |
| US-6004983-A | ANALGESICS; ANTIINFLAMMATORY, ANTIARTHRITIC AND ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DE) | 1999-12-21 | — | — | US | disclosed |
| EP-0934313-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015549-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |