Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL6965830 | 0.91 | KDM4E (0.42) | KDM4EALDH1A1KMT2ATSHRSMN1; SMN2 | |
| Oxalic Acid SCHEMBL6964376 | 0.90 | ALDH1A1 (0.49) | KDM4EALDH1A1KMT2ASMN1; SMN2CYP2D6 | |
| Oxalic Acid SCHEMBL6959081 | 0.90 | ALDH1A1 (0.49) | KDM4EALDH1A1KMT2ASMN1; SMN2CYP2D6 | |
| SCHEMBL6955699 | 0.88 | SIGMAR1 (0.50) | KDM4EALDH1A1KMT2ATSHRLMNA | |
| SCHEMBL6963328 | 0.85 | LMNA (0.49) | KDM4EALDH1A1LMNASMN1; SMN2LTA4H | |
| Hydrochloric Acid SCHEMBL6964854 | 0.84 | LMNA (0.51) | KDM4EALDH1A1LMNASMN1; SMN2LTA4H | |
| SCHEMBL6964102 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1KMT2ATSHRSMN1; SMN2 | |
| Oxalic Acid SCHEMBL6969816 | 0.82 | RAB9A (0.54) | KDM4EALDH1A1KMT2ATSHRLTA4H | |
| Oxalic Acid SCHEMBL6959493 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1TSHRSMN1; SMN2CYP2D6 | |
| SCHEMBL7813214 | 0.81 | ALDH1A1 (0.52) | KDM4EALDH1A1LMNASMN1; SMN2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934313-B1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2003-05-14 | — | — | EP | disclosed |
| US-6004983-A | ANALGESICS; ANTIINFLAMMATORY, ANTIARTHRITIC AND ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DE) | 1999-12-21 | — | — | US | disclosed |
| EP-0934313-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015549-A1 | N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-04-16 | — | — | WO | disclosed |