Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.44 |
| ▸ | SCD | O00767 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187453 | 0.88 | CYP11B2 (0.47) | CYP11B2CYP11B1HSP90B1MEN1KMT2A | |
| SCHEMBL20591090 | 0.85 | SCD (0.50) | CYP11B2CYP11B1SMN1; SMN2HSP90AA1HSP90B1 | |
| SCHEMBL28895492 | 0.80 | PKM (0.58) | CYP11B2CYP11B1SMN1; SMN2HSP90AA1HSP90B1 | |
| SCHEMBL7009864 | 0.80 | YTHDC1 (0.46) | CYP11B2CYP11B1HSP90AA1HSP90B1YTHDC1 | |
| SCHEMBL20591091 | 0.80 | SCD (0.46) | CYP11B2CYP11B1HSP90AA1HSP90B1YTHDC1 | |
| SCHEMBL17465809 | 0.79 | GAA (0.50) | CYP11B2CYP11B1SMN1; SMN2HSP90AA1HSP90B1 | |
| SCHEMBL6981816 | 0.78 | OPRD1 (0.48) | ALDH1A1 | |
| SCHEMBL3876222 | 0.76 | YTHDC1 (0.52) | CYP11B2SMN1; SMN2YTHDC1RAB9A | |
| SCHEMBL20591084 | 0.74 | PKM (0.47) | CYP11B2CYP11B1SMN1; SMN2HSP90AA1HSP90B1 | |
| SCHEMBL20591088 | 0.73 | CYP11B2 (0.48) | CYP11B2CYP11B1HSP90AA1HSP90B1YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |