Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964899 | 0.89 | HRH1 (0.40) | HRH1ADRA2AADRA1ALMNAHTR1A | |
| SCHEMBL6971128 | 0.87 | CCR1 (0.44) | CCR1CHRM2CCR5HRH1ADRA2A | |
| Hydrochloric Acid SCHEMBL6969045 | 0.86 | CCR1 (0.43) | CCR1CHRM2CCR5HRH1ADRA2A | |
| SCHEMBL6971968 | 0.83 | MAPT (0.42) | CCR1CHRM2CCR5HRH1ADRA2A | |
| SCHEMBL6973725 | 0.79 | HRH1 (0.47) | HRH1ADRA1AHTR1ADRD2DRD3 | |
| SCHEMBL6971120 | 0.79 | DRD2 (0.42) | HRH1HTR2AADRA1ALMNAHTR1A | |
| SCHEMBL6960366 | 0.75 | HRH1 (0.44) | CCR1CHRM2CCR5HRH1ADRA1A | |
| Hydrochloric Acid SCHEMBL6960538 | 0.74 | HRH1 (0.43) | CCR1CHRM2CCR5HRH1ADRA1A | |
| SCHEMBL6960765 | 0.74 | HRH1 (0.42) | CHRM2HRH1ADRA2AHTR2AADRA1A | |
| SCHEMBL6964674 | 0.73 | DRD2 (0.48) | HTR2AHTR1ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934312-B1 | 1,4-DISUBSTITUTED PIPERAZINES | NOVO NORDISK AS (DK) | 2003-03-19 | — | — | EP | claimed |