Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.41 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.40 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979211 | 0.79 | RAB9A (0.58) | RAB9ANPC1HPGDSMN1; SMN2MAOB | |
| SCHEMBL6979685 | 0.78 | GAA (0.47) | PLOD2PLOD3PLOD1AKR1A1AKR1B1 | |
| SCHEMBL7960065 | 0.76 | AKR1A1 (0.43) | AKR1A1AKR1B1RAB9ANPC1HPGD | |
| SCHEMBL19691127 | 0.75 | DYRK1A (0.43) | AKR1A1AKR1B1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6977213 | 0.75 | GAA (0.40) | AKR1A1AKR1B1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6981786 | 0.73 | DYRK1A (0.49) | PLOD2PLOD3PLOD1AKR1A1AKR1B1 | |
| SCHEMBL6982879 | 0.73 | PDPK1 (0.49) | PLOD2RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL6969298 | 0.71 | STING1 (0.39) | PLOD2PLOD3PLOD1MAOBHSD17B1 | |
| SCHEMBL8643935 | 0.71 | PLOD2 (0.55) | PLOD2PLOD3PLOD1RAB9ANPC1 | |
| Trifluoroacetic Acid SCHEMBL29974297 | 0.70 | SMN1; SMN2 (0.41) | AKR1A1AKR1B1RAB9ANPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-1006114-A1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | Grelan Pharmaceutical Co., Ltd. (JP) | 2000-06-07 | — | — | EP | disclosed |