Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | PLOD2 | O00469 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.40 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982879 | 0.89 | PDPK1 (0.49) | DYRK1APLOD2MAOBNPC1RAB9A | |
| SCHEMBL6979211 | 0.82 | RAB9A (0.58) | MAOBNPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL6969298 | 0.79 | STING1 (0.39) | PLOD2MAOBPLOD3PLOD1 | |
| SCHEMBL6975865 | 0.77 | TP53 (0.51) | DYRK1AMAOBNPC1RAB9AHPGD | |
| SCHEMBL6983733 | 0.77 | DYRK1A (0.48) | DYRK1AMAOBNPC1RAB9AHPGD | |
| SCHEMBL3642370 | 0.76 | DYRK1A (0.55) | DYRK1AMAOBHDAC6HDAC3HDAC1 | |
| SCHEMBL6982986 | 0.75 | DYRK1A (0.61) | DYRK1AHDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL417526 | 0.75 | DYRK1A (0.54) | DYRK1AMAOBHDAC6HDAC3HDAC1 | |
| SCHEMBL6979367 | 0.74 | MAPT (0.57) | DYRK1AMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6979685 | 0.73 | GAA (0.47) | PLOD2PLOD3PLOD1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |