Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981786 | 0.89 | DYRK1A (0.49) | PDPK1DYRK1AMAOBPLOD2SMYD3 | |
| SCHEMBL6983733 | 0.85 | DYRK1A (0.48) | DYRK1AMAOBKDM4EMEN1LMNA | |
| SCHEMBL6975865 | 0.85 | TP53 (0.51) | DYRK1AMAOBKDM4EMEN1LMNA | |
| SCHEMBL6979336 | 0.82 | PDPK1 (0.50) | PDPK1DYRK1AMAOBSMYD3LRRK2 | |
| SCHEMBL6979367 | 0.82 | MAPT (0.57) | DYRK1AMAOBMEN1MAPTKMT2A | |
| SCHEMBL6979211 | 0.82 | RAB9A (0.58) | MAOBMEN1LMNAMAPTKMT2A | |
| SCHEMBL6969298 | 0.79 | STING1 (0.39) | MAOBPLOD2GAA | |
| SCHEMBL14020422 | 0.78 | HSD17B1 (0.57) | PDPK1DYRK1AMAOBSMYD3LRRK2 | |
| SCHEMBL25215416 | 0.77 | SMYD3 (0.60) | PDPK1DYRK1AMAOBSMYD3LRRK2 | |
| SCHEMBL30039643 | 0.77 | SMYD3 (0.60) | PDPK1DYRK1AMAOBSMYD3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1006114-B1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | GRELAN PHARMACEUTICAL CO (JP) | 2003-01-22 | — | — | EP | disclosed |
| US-6136831-A | ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL AGENTS, ENZYME INHIBITORS | GRELAN PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |
| EP-1006114-A1 | PYRAZOLE DERIVATIVES AND COX INHIBITORS CONTAINING THEM | Grelan Pharmaceutical Co., Ltd. (JP) | 2000-06-07 | — | — | EP | disclosed |