Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.37 |
| ▸ | HTR1A | P08908 | 7/20 | 0.37 |
| ▸ | DRD1 | P21728 | 7/20 | 0.37 |
| ▸ | DRD4 | P21917 | 7/20 | 0.37 |
| ▸ | DRD5 | P21918 | 7/20 | 0.37 |
| ▸ | DRD2 | P14416 | 7/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972322 | 1.00 | DRD3 (0.37) | DRD3HTR1ADRD1DRD4DRD5 | |
| SCHEMBL6973703 | 0.88 | CCR8 (0.48) | CCR8KCNH2 | |
| SCHEMBL6973699 | 0.88 | CCR8 (0.48) | CCR8KCNH2 | |
| SCHEMBL6965739 | 0.80 | DRD3 (0.45) | DRD3HTR1ADRD1DRD4DRD5 | |
| SCHEMBL6978175 | 0.78 | HTR1A (0.38) | HTR1ADRD2 | |
| SCHEMBL6966304 | 0.76 | TRPV1 (0.34) | — | |
| SCHEMBL6966308 | 0.76 | TRPV1 (0.34) | — | |
| SCHEMBL8124875 | 0.76 | ENPP1 (0.35) | DRD3HTR1ADRD4DRD2KCNH2 | |
| SCHEMBL22728221 | 0.72 | TYR (0.51) | MEN1TP53CYP3A4ALOX5MAPT | |
| SCHEMBL6975728 | 0.71 | CCR8 (0.56) | CCR8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051413-B1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2003-06-04 | — | — | EP | disclosed |
| EP-1051413-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037635-A1 | QUINOLINE DERIVATIVES AS ANTIBACTERIALS | SMITHKLINE BEECHAM PLC (GB) | 1999-07-29 | — | — | WO | disclosed |