Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979964 | 0.91 | CHEK2 (0.46) | TBK1TOP2AGPR119RAF1BRAF | |
| SCHEMBL6975780 | 0.89 | TBK1 (0.43) | TBK1ALDH1A1RAF1BRAFPIK3CA | |
| SCHEMBL6973788 | 0.85 | TBK1 (0.44) | TBK1PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6972611 | 0.83 | MAPK14 (0.57) | MEN1ALDH1A1MAPTPKMKMT2A | |
| SCHEMBL6477326 | 0.79 | MAPK14 (0.54) | PDE4DPDE4BPDE4APDE4CMEN1 | |
| SCHEMBL7806485 | 0.78 | MAPT (0.50) | TBK1PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6972610 | 0.76 | PDE4D (0.41) | TBK1PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL6979962 | 0.73 | MAPK14 (0.61) | RAF1BRAF | |
| SCHEMBL6574087 | 0.73 | RAF1 (0.44) | MEN1ALDH1A1MAPTPKMKMT2A | |
| SCHEMBL6969091 | 0.72 | MAPK14 (0.42) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |