Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | ATR | Q13535 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | RAF1 | P04049 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | SMO | Q99835 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975780 | 0.93 | TBK1 (0.43) | CHEK2TBK1PIK3CAMTORPIK3CG | |
| SCHEMBL6972614 | 0.91 | TBK1 (0.47) | TBK1PIK3CAMTORPIK3CGATR | |
| SCHEMBL6973788 | 0.89 | TBK1 (0.44) | CHEK2TBK1PIK3CAMTORPIK3CG | |
| SCHEMBL6979962 | 0.81 | MAPK14 (0.61) | MAPK14RAF1BRAFSMO | |
| SCHEMBL7809442 | 0.76 | MAPK14 (0.52) | GPR119MAPK14SMO | |
| SCHEMBL6476511 | 0.76 | MAPK14 (0.62) | GPR119MAPK14RAF1BRAFSMO | |
| SCHEMBL7835408 | 0.75 | MAPK14 (0.63) | MAPK14RAF1BRAF | |
| SCHEMBL6979960 | 0.74 | CHEK2 (0.41) | CHEK2TBK1GPR119TOP2A | |
| SCHEMBL18319173 | 0.74 | TBK1 (0.48) | CHEK2TBK1PIK3CAMTORPIK3CG | |
| SCHEMBL6975779 | 0.74 | MAPK14 (0.58) | MAPK14RAF1BRAFSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |