Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 6/20 | 0.41 |
| ▸ | BRAF | P15056 | 6/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6973788 | 0.96 | TBK1 (0.44) | TBK1RAF1BRAFPIK3CAMTOR | |
| SCHEMBL6979964 | 0.93 | CHEK2 (0.46) | TBK1RAF1BRAFPIK3CAMTOR | |
| SCHEMBL6972614 | 0.89 | TBK1 (0.47) | TBK1RAF1BRAFPIK3CAMTOR | |
| SCHEMBL6975779 | 0.82 | MAPK14 (0.58) | RAF1BRAFMAPK14SMO | |
| SCHEMBL6969091 | 0.80 | MAPK14 (0.42) | MAPK14ALDH1A1SMN1; SMN2SMOTSHR | |
| SCHEMBL6476766 | 0.79 | OPRK1 (0.59) | RAF1BRAFMAPK14OPRK1ALDH1A1 | |
| SCHEMBL2972096 | 0.79 | OPRK1 (0.58) | RAF1BRAFMAPK14OPRK1SMO | |
| SCHEMBL7804552 | 0.78 | OPRK1 (0.54) | MAPK14OPRK1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL6973786 | 0.78 | MAPK14 (0.57) | RAF1BRAFMAPK14SMO | |
| SCHEMBL6477083 | 0.76 | MAPK14 (0.54) | BRAFMAPK14OPRK1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |