Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 7/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 4/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979960 | 0.91 | CHEK2 (0.41) | TOP2ATBK1KMT2A | |
| SCHEMBL6975773 | 0.90 | RAB9A (0.38) | TOP2ATBK1MEN1ALDH1A1KMT2A | |
| SCHEMBL6973782 | 0.86 | TBK1 (0.36) | TOP2ATBK1MEN1ALDH1A1KMT2A | |
| SCHEMBL6972614 | 0.76 | TBK1 (0.47) | PDE4DPDE4BPDE4APDE4CTOP2A | |
| SCHEMBL6477326 | 0.75 | MAPK14 (0.54) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL7806485 | 0.74 | MAPT (0.50) | PDE4DPDE4BPDE4APDE4CTOP2A | |
| SCHEMBL6972611 | 0.74 | MAPK14 (0.57) | MEN1ALDH1A1MAPTPKMKMT2A | |
| SCHEMBL6486054 | 0.67 | PDE4B (0.69) | PDE4DPDE4BPDE4APDE4CTOP2A | |
| SCHEMBL2972096 | 0.66 | OPRK1 (0.58) | — | |
| SCHEMBL6979964 | 0.66 | CHEK2 (0.46) | TOP2ATBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115707-B1 | BENZAMIDE DERIVATIVES AND THER USE AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2003-11-12 | — | — | EP | disclosed |