Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 8/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14001658 | 0.93 | P2RX3 (0.35) | P2RX3TBXA2RTP53MAPTTDP1 | |
| SCHEMBL13996465 | 0.93 | P2RX3 (0.41) | P2RX3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6967638 | 0.91 | TDP1 (0.39) | P2RX3TP53MAPTALDH1A1TDP1 | |
| SCHEMBL6975100 | 0.91 | TDP1 (0.33) | P2RX3TP53MAPTHPGDSMN1; SMN2 | |
| SCHEMBL6966285 | 0.91 | P2RX3 (0.33) | P2RX3KDM4EALDH1A1HPGDSMN1; SMN2 | |
| Capravirine SCHEMBL40347 | 0.91 | PIM1 (0.35) | P2RX3MAPTKDM4EALDH1A1SMN1; SMN2 | |
| Capravirine SCHEMBL4656686 | 0.91 | PIM1 (0.35) | P2RX3MAPTKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14439871 | 0.90 | P2RX3 (0.33) | P2RX3MAPT | |
| SCHEMBL6973048 | 0.90 | ENPP2 (0.35) | P2RX3TBXA2RALDH1A1SMN1; SMN2CCR5 | |
| SCHEMBL14439866 | 0.89 | L3MBTL1 (0.38) | TBXA2RTP53MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070190523-A1 | Method and compositions for identifying anti-hiv therapeutic compounds | GILEAD SCIENCES, INC. | 2007-08-16 | — | — | US | disclosed |
| US-20070190523-A1 | Method and compositions for identifying anti-hiv therapeutic compounds | GILEAD SCIENCES, INC. | 2007-08-16 | — | — | US | disclosed |
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |