Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 5/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.31 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 3/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6962112 | 0.95 | PPARG (0.34) | P2RX3PPARG | |
| SCHEMBL6973223 | 0.91 | TDP1 (0.33) | P2RX3KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6973396 | 0.91 | PIM1 (0.34) | P2RX3HSP90B1TRAP1TDP1 | |
| SCHEMBL6972846 | 0.91 | P2RX3 (0.34) | P2RX3KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6967033 | 0.90 | ENPP2 (0.31) | ALDH1A1SMN1; SMN2PPARG | |
| SCHEMBL6962314 | 0.89 | L3MBTL1 (0.36) | SLC6A2SLC6A4SLC6A3ALDH1A1HPGD | |
| SCHEMBL6973181 | 0.88 | P2RX3 (0.34) | P2RX3PPARG | |
| SCHEMBL6966178 | 0.87 | ADRA1D (0.36) | P2RX3HSP90B1ALDH1A1 | |
| SCHEMBL6964951 | 0.87 | ALDH1A1 (0.32) | P2RX3KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6969256 | 0.87 | HSP90B1 (0.30) | HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |