Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GALR2 | O43603 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28980700 | 0.81 | RECQL (0.43) | LMNARECQLKMT2AMEN1MAPT | |
| SCHEMBL6593159 | 0.79 | LMNA (0.68) | LMNARECQLKMT2AMEN1L3MBTL1 | |
| SCHEMBL6974150 | 0.77 | L3MBTL1 (0.45) | LMNARECQLKMT2AMEN1L3MBTL1 | |
| SCHEMBL21765907 | 0.77 | TSHR (0.51) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL28829630 | 0.76 | MAPT (0.49) | LMNARECQLKMT2AMEN1MAPT | |
| SCHEMBL12824738 | 0.76 | L3MBTL1 (0.41) | LMNARECQLKMT2AMEN1L3MBTL1 | |
| SCHEMBL9846815 | 0.75 | MEN1 (0.41) | LMNARECQLKMT2AMEN1MAPT | |
| SCHEMBL6114931 | 0.74 | KMT2A (0.78) | LMNAKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2309925 | 0.74 | LMNA (0.50) | LMNAKMT2AMEN1L3MBTL1MAPT | |
| SCHEMBL30748250 | 0.74 | NPSR1 (0.50) | LMNAKMT2AMEN1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |