Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12824738 | 0.80 | L3MBTL1 (0.41) | L3MBTL1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6974180 | 0.78 | ALDH1A1 (0.46) | HDAC1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL6973377 | 0.77 | LMNA (0.47) | L3MBTL1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL1465528 | 0.76 | LMNA (0.38) | L3MBTL1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL5182303 | 0.76 | LMNA (0.69) | L3MBTL1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL28829630 | 0.75 | MAPT (0.49) | HDAC1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL30152255 | 0.74 | GAA (0.45) | L3MBTL1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL11281301 | 0.72 | KMT2A (0.73) | L3MBTL1HDAC1LMNAMEN1KMT2A | |
| SCHEMBL11043074 | 0.70 | L3MBTL1 (0.52) | L3MBTL1HDAC1LMNAMEN1KMT2A | |
| SCHEMBL15239774 | 0.70 | HCAR3 (0.54) | L3MBTL1LMNAALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |