Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4652737 | 0.78 | MAPT (0.54) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6675030 | 0.77 | MEN1 (0.45) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6973377 | 0.76 | LMNA (0.47) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL19124186 | 0.75 | MAPT (0.42) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL2221711 | 0.75 | MAPT (0.42) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL16115326 | 0.75 | MAPT (0.42) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL6974150 | 0.75 | L3MBTL1 (0.45) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL10420552 | 0.73 | PDK1 (0.44) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL16174698 | 0.73 | MAPT (0.40) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12824738 | 0.73 | L3MBTL1 (0.41) | MAPTMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102596957-B | Substituted pyrazolo [1,5-a ] pyrimidine compounds as TRK kinase inhibitors | 阵列生物制药公司 | 2016-06-29 | — | — | CN | disclosed |