SCHEMBL6973409

SCHEMBL6973409

CC(C)c1[nH]c(C(O)Cc2ccncc2)nc1Sc1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 2/20 0.36
CYP3A4 P08684 3/20 0.36
ALDH1A1 P00352 2/20 0.36
TRPA1 O75762 1/20 0.35
CYP1A2 P05177 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
CYP2D6 P10635 1/20 0.34
HIF1A Q16665 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
SLC6A2 P23975 1/20 0.33
SLC6A3 Q01959 1/20 0.33
ROCK2 O75116 1/20 0.32
CDK5 Q00535 1/20 0.32
CDK5R1 Q15078 1/20 0.32
KMT2A Q03164 1/20 0.32
MAPK13 O15264 1/20 0.32
MAPK12 P53778 1/20 0.32
MAPK11 Q15759 1/20 0.32
MAPK14 Q16539 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6974320 0.87 MAPK14 (0.34) CYP3A4ROCK2MAPK13MAPK12MAPK11
SCHEMBL7082933 0.87 CSNK2A2 (0.38) CYP3A4ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL6973795 0.86 GSK3B (0.32) CYP3A4CYP1A2CYP2C9CYP2C19CDK5
SCHEMBL6968179 0.85 CYP1A2 (0.33) CYP3A4CYP1A2CYP2C9CYP2C19
SCHEMBL6974054 0.85 GSK3B (0.32) CYP3A4CYP1A2CYP2C9CYP2C19ROCK2
SCHEMBL7079125 0.84 ALDH1A1 (0.36) SLC6A4CYP3A4ALDH1A1HDAC6ROCK2
SCHEMBL6967049 0.84 LMNA (0.37) SLC6A4ALDH1A1TRPA1HDAC6KMT2A
SCHEMBL6972450 0.83 CDK5 (0.32) SLC6A4CYP3A4ALDH1A1CYP1A2CYP2C9
SCHEMBL6968078 0.83 ALOX5 (0.38) CYP3A4ALDH1A1CYP1A2CYP2C9CYP2C19
SCHEMBL6973960 0.82 IDO1 (0.38) SLC6A4ALDH1A1TRPA1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed