Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCAT | P04180 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 9/20 | 0.36 |
| ▸ | DRD2 | P14416 | 8/20 | 0.36 |
| ▸ | DRD3 | P35462 | 7/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6977630 | 0.89 | MAPT (0.38) | LCATMAPTALDH1A1 | |
| SCHEMBL6964321 | 0.87 | MAPT (0.40) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL6974758 | 0.77 | DRD2 (0.36) | LCATDRD4DRD2DRD3MAPK13 | |
| SCHEMBL8308786 | 0.76 | DRD4 (0.43) | DRD4DRD2DRD3MAPK13MAPK12 | |
| SCHEMBL6959299 | 0.74 | MEN1 (0.42) | DRD4DRD2DRD3MAPTLMNA | |
| SCHEMBL8148732 | 0.72 | ADRA2A (0.37) | DRD3MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6966648 | 0.72 | TP53 (0.41) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL6965770 | 0.72 | MAPT (0.42) | DRD4DRD2DRD3MAPTALDH1A1 | |
| SCHEMBL6956633 | 0.69 | MAPT (0.44) | MAPTALDH1A1LMNARAB9ANPC1 | |
| SCHEMBL6956780 | 0.69 | MAP4K1 (0.42) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0945439-B1 | AMINOPYRAZOLE DERIVATIVES | BANYU PHARMA CO LTD (JP) | 2003-03-19 | — | — | EP | disclosed |
| US-6166038-A | Aminopyrazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2000-12-26 | — | — | US | disclosed |
| EP-0945439-A1 | NOVEL AMINOPYRAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1999-09-29 | — | — | EP | disclosed |