Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | DRD3 | P35462 | 6/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388392 | 0.84 | DRD4 (0.60) | DRD4DRD2DRD3ALDH1A1CYP1A2 | |
| SCHEMBL1388702 | 0.81 | DRD4 (0.66) | DRD4DRD2DRD3ALDH1A1CYP1A2 | |
| SCHEMBL6974758 | 0.76 | DRD2 (0.36) | DRD4DRD2DRD3MAPK13MAPK12 | |
| SCHEMBL6974762 | 0.76 | LCAT (0.37) | DRD4DRD2DRD3MAPK13MAPK12 | |
| SCHEMBL1388459 | 0.71 | ALDH1A1 (0.45) | DRD4DRD2DRD3ALDH1A1LMNA | |
| SCHEMBL1388772 | 0.70 | TRPV6 (0.47) | DRD4DRD2DRD3ALDH1A1TSHR | |
| SCHEMBL31612521 | 0.70 | MEN1 (0.61) | DRD4DRD2ALDH1A1CYP1A2LMNA | |
| SCHEMBL15657195 | 0.69 | GRM5 (0.40) | DRD4DRD2DRD3ALDH1A1CYP1A2 | |
| SCHEMBL1388752 | 0.68 | SIGMAR1 (0.55) | DRD4DRD2DRD3ALDH1A1CYP1A2 | |
| SCHEMBL23630311 | 0.68 | ALDH1A1 (0.43) | DRD4DRD2DRD3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665833-B1 | DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME (GB) | 1999-07-14 | — | — | EP | claimed |