SCHEMBL6976466

SCHEMBL6976466

COC(=O)c1cc2c(=O)ccn3c4ccccc4c(c1)c23

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 3/20 0.43
SCARB1 Q8WTV0 1/20 0.43
KMT2A Q03164 4/20 0.41
ALDH1A1 P00352 3/20 0.41
MAPT P10636 2/20 0.41
KDM4E B2RXH2 1/20 0.41
THRB P10828 1/20 0.41
MEN1 O00255 1/20 0.41
POLB P06746 1/20 0.41
FTO Q9C0B1 1/20 0.40
PMM2 O15305 1/20 0.40
MPI P34949 1/20 0.40
RAB9A P51151 1/20 0.40
PHOSPHO1 Q8TCT1 1/20 0.40
HPGD P15428 1/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
LMNA P02545 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6975999 0.83 KDM4E (0.47) KMT2AALDH1A1KDM4EMEN1PMM2
SCHEMBL6976281 0.82 NPC1 (0.41) KMT2AALDH1A1MAPTKDM4EMEN1
SCHEMBL6979690 0.77 MEN1 (0.36) KMT2AALDH1A1MAPTKDM4EMEN1
SCHEMBL6979022 0.75 PGR (0.39) KMT2AALDH1A1MAPTKDM4EMEN1
SCHEMBL6980643 0.73 KDM4E (0.42) KMT2AALDH1A1MAPTKDM4EMEN1
SCHEMBL7929751 0.73 FTO (0.51) NR4A2SCARB1ALDH1A1MAPTKDM4E
SCHEMBL6976283 0.72 CA1 (0.43) ALDH1A1KDM4EHPGD
SCHEMBL986790 0.71 TSHR (0.48) NR4A2KMT2AALDH1A1MAPTKDM4E
SCHEMBL3663983 0.68 PTGER4 (0.46) NR4A2KMT2AALDH1A1KDM4ETHRB
SCHEMBL7662145 0.67 P2RX4 (0.43) KMT2AALDH1A1MAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985671-B1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARM CO LTD (JP) 2003-04-02 EP disclosed
US-6197768-B1 THERAPY, PREVENTION ISCHEMIC HEART DISEASE MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2001-03-06 US disclosed
EP-0985671-A1 PYRIDOCARBAZOLE DERIVATIVES HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed
US-6018046-A SELECTIVE ACTION IN INHIBITING CYCLIC GMP-PHOSPHODIESTERASE (CGMP-PDE); PHARMACEUTICALS FOR TREATING DISEASES AGAINST WHICH THE INHIBITORY ACTION IS EFFECTIVE, SUCH AS PULMONARY HYPERTENSION MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-01-25 US disclosed