Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ME2 | P23368 | 1/20 | 0.40 |
| ▸ | ME1 | P48163 | 1/20 | 0.40 |
| ▸ | ME3 | Q16798 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974103 | 0.94 | NPC1 (0.48) | L3MBTL1TSHRFKBP1ANPC1TDP1 | |
| SCHEMBL6983252 | 0.88 | CACNA1B (0.36) | — | |
| Hydrochloric Acid SCHEMBL6984012 | 0.82 | SIGMAR1 (0.45) | POLBSIGMAR1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6975998 | 0.82 | TSHR (0.44) | TSHRALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL6976497 | 0.80 | CARM1 (0.42) | — | |
| SCHEMBL6984706 | 0.79 | ALDH1A1 (0.40) | POLBALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL6981795 | 0.78 | POLB (0.47) | TSHRPOLBALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6980208 | 0.75 | CARM1 (0.43) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6986400 | 0.73 | HTR1A (0.41) | TDP1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6983932 | 0.70 | CHRM2 (0.43) | NPC1SIGMAR1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |