Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 3/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 2/20 | 0.36 |
| ▸ | PRKCH | P24723 | 1/20 | 0.36 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007072 | 0.80 | PRKCA (0.45) | PIM1CAMK2DPRKCAPRKACAPRKACG | |
| SCHEMBL8079796 | 0.79 | PIM1 (0.65) | PIM1CAMK2DPRKCAPRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL8319144 | 0.78 | PIM1 (0.64) | PIM1CAMK2DPRKCAPRKACAPRKACG | |
| SCHEMBL7007161 | 0.77 | CAMK2D (0.57) | PIM1CAMK2DRPS6KB1PRKCAPRKACA | |
| Acetic Acid SCHEMBL7005590 | 0.77 | PRKCB (0.44) | PIM1CAMK2DPRKCAPRKCBPRKCH | |
| SCHEMBL7005430 | 0.72 | CAMK2D (0.59) | PIM1CAMK2DRPS6KB1PRKACAPRKACG | |
| Trifluoroacetic Acid SCHEMBL7007891 | 0.71 | CAMK2D (0.49) | PIM1CAMK2DRPS6KB1PRKCAPRKACA | |
| SCHEMBL7826748 | 0.71 | PRKCA (0.46) | PIM1CAMK2DPRKCAPRKACAPRKACG | |
| SCHEMBL7826749 | 0.70 | CAMK2D (0.40) | PIM1CAMK2DPRKACAPRKACGPRKACB | |
| SCHEMBL7005539 | 0.70 | CDK4 (0.55) | PIM1CAMK2DRPS6KB1PRKCAPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | claimed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | claimed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | claimed |
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |