Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 5/20 | 0.45 |
| ▸ | PRKCB | P05771 | 4/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | PRKACG | P22612 | 1/20 | 0.37 |
| ▸ | PRKACB | P22694 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7005590 | 0.96 | PRKCB (0.44) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| SCHEMBL7008945 | 0.84 | PRKACA (0.43) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| SCHEMBL7007161 | 0.82 | CAMK2D (0.57) | PRKCAPIM1CAMK2DPRKACAPRKACG | |
| SCHEMBL6977921 | 0.80 | PIM1 (0.42) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| SCHEMBL6974638 | 0.79 | PRKCB (0.40) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| SCHEMBL8065185 | 0.78 | PRKCA (0.68) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL7006503 | 0.77 | TPSAB1 (0.43) | CAMK2DSIRT2PRKACAPRKACGPRKACB | |
| Hydrochloric Acid SCHEMBL8064918 | 0.77 | PRKCA (0.67) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL7007891 | 0.75 | CAMK2D (0.49) | PRKCAPRKCBPRKCDPRKCHPRKCE | |
| Trifluoroacetic Acid SCHEMBL6981001 | 0.74 | TPSAB1 (0.41) | PRKCAPRKCBPRKCDPRKCHPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | claimed |
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |