Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 4/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | PRKACG | P22612 | 2/20 | 0.46 |
| ▸ | PRKACB | P22694 | 2/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7007891 | 0.92 | CAMK2D (0.49) | CAMK2DPIM1RPS6KB1PRKACAPRKACG | |
| SCHEMBL7007072 | 0.82 | PRKCA (0.45) | CAMK2DPIM1PRKACAPRKACGPRKACB | |
| SCHEMBL7005430 | 0.80 | CAMK2D (0.59) | CAMK2DPIM1RPS6KB1PRKACAPRKACG | |
| SCHEMBL7007889 | 0.80 | CAMK2D (0.62) | CAMK2DPIM1RPS6KB1PRKACAPRKACG | |
| Acetic Acid SCHEMBL7005590 | 0.79 | PRKCB (0.44) | CAMK2DPIM1PRKCACCNT1CDK9 | |
| SCHEMBL7008865 | 0.78 | PIM1 (0.40) | CAMK2DPIM1CCNT1CDK9 | |
| SCHEMBL6973734 | 0.78 | CAMK2D (0.56) | CAMK2DPIM1RPS6KB1PRKACAPRKACG | |
| SCHEMBL7005539 | 0.78 | CDK4 (0.55) | CAMK2DPIM1RPS6KB1PRKACAPRKACG | |
| SCHEMBL6977921 | 0.77 | PIM1 (0.42) | CAMK2DPIM1RPS6KB1PRKACAPRKACG | |
| SCHEMBL7004584 | 0.77 | CAMK2D (0.61) | CAMK2DPIM1RPS6KB1PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | claimed |
| US-6337342-B1 | ARYLIMIDAZOLONE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-01-08 | — | — | US | claimed |
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |