Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 11/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6979329 | 0.85 | ALDH1A1 (0.41) | PTGIRPTGDRHTR1AKLKB1POLB | |
| SCHEMBL6978595 | 0.75 | CA2 (0.39) | HTR1ATP53 | |
| SCHEMBL6978931 | 0.75 | HTR1A (0.40) | PTGIRHTR1ATP53 | |
| SCHEMBL6970471 | 0.74 | SIRT1 (0.47) | HTR1A | |
| SCHEMBL730472 | 0.74 | PTGIR (0.46) | PTGIR | |
| SCHEMBL6967828 | 0.74 | GRM2 (0.46) | HTR1A | |
| SCHEMBL6971601 | 0.72 | HTR1A (0.39) | PTGIRHTR1ATP53 | |
| SCHEMBL2190445 | 0.72 | PTGIR (0.46) | PTGIRHTR1A | |
| SCHEMBL5100424 | 0.72 | PTGIR (0.46) | PTGIRHTR1A | |
| SCHEMBL6978896 | 0.72 | HTR1A (0.47) | PTGIRHTR1AKLKB1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6313114-B1 | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |