Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6981421 | 0.88 | ALDH1A1 (0.42) | CAMK2DSMN1; SMN2KMT2APIM1ALDH1A1 | |
| SCHEMBL6981894 | 0.87 | MAPT (0.37) | CAMK2DSMN1; SMN2KMT2APIM1FLT3 | |
| SCHEMBL7812900 | 0.83 | SMN1; SMN2 (0.36) | CAMK2DSMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL6980034 | 0.76 | CCNT1 (0.48) | CAMK2DSMN1; SMN2KMT2APIM1CREBBP | |
| SCHEMBL6978208 | 0.76 | CNR1 (0.40) | ALDH1A1CNR1CA12CA1CA2 | |
| SCHEMBL6981135 | 0.75 | ALDH1A1 (0.40) | CAMK2DSMN1; SMN2KMT2AGSK3BALDH1A1 | |
| SCHEMBL6985899 | 0.75 | MAPT (0.40) | SMN1; SMN2KMT2AALDH1A1MEN1NPC1 | |
| SCHEMBL7005879 | 0.75 | PIM1 (0.48) | CAMK2DSMN1; SMN2KMT2APIM1GSK3B | |
| Acetic Acid SCHEMBL7011660 | 0.75 | CAMK2D (0.46) | CAMK2DSMN1; SMN2KMT2APIM1GSK3B | |
| SCHEMBL7011646 | 0.74 | ALDH1A1 (0.39) | CAMK2DSMN1; SMN2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-B1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2003-08-27 | — | — | EP | disclosed |
| US-6346625-B1 | ENZYME INHIBITORS FOR PROTEIN KINASES | ASTRAZENECA AB (SE) | 2002-02-12 | — | — | US | disclosed |
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |