Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASK | O14936 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | STK10 | O94804 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | PRKCB | P05771 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL7011660 | 0.97 | CAMK2D (0.46) | PIM1CAMK2DCNR1CCNT1CDK9 | |
| SCHEMBL7005313 | 0.82 | PKM (0.40) | CNR1CDK2PRKCBMAPTPRKCA | |
| SCHEMBL6975872 | 0.77 | CNR1 (0.44) | PIM1CAMK2DCNR1CCNT1CDK9 | |
| SCHEMBL6973734 | 0.77 | CAMK2D (0.56) | PIM1CAMK2DCCNT1CDK9CCNA2 | |
| SCHEMBL7007161 | 0.77 | CAMK2D (0.57) | PIM1CAMK2DCCNT1CDK9PRKCA | |
| Hydrochloric Acid SCHEMBL6984367 | 0.77 | CAMK2D (0.55) | PIM1CAMK2DCCNT1CDK9CCNA2 | |
| SCHEMBL6975973 | 0.77 | CAMK2D (0.53) | PIM1CAMK2DCCNT1CDK9CCNA2 | |
| SCHEMBL6979608 | 0.75 | CAMK2D (0.35) | PIM1CAMK2DCNR1MEN1GSK3B | |
| SCHEMBL6981421 | 0.74 | ALDH1A1 (0.42) | PIM1CAMK2DCNR1MEN1CYP3A4 | |
| Trifluoroacetic Acid SCHEMBL6982808 | 0.74 | CAMK2D (0.46) | PIM1CAMK2DCCNT1CDK9CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | claimed |
| US-6337342-B1 | ARYLIMIDAZOLONE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-01-08 | — | — | US | claimed |
| EP-1028955-B1 | PYRIMIDINONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BEECHAM PLC (GB) | 2003-07-16 | — | — | EP | disclosed |
| EP-1042317-B1 | Indole derivatives as PKC-inhiboitors | ASTRAZENECA AB (SE) | 2003-05-14 | — | — | EP | disclosed |