Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976497 | 0.90 | CARM1 (0.42) | PRMT6CARM1 | |
| SCHEMBL6981079 | 0.88 | HRH3 (0.40) | PRMT6CARM1CCR3SIGMAR1 | |
| SCHEMBL6981931 | 0.87 | HRH3 (0.39) | PRMT6CARM1CCR3SIGMAR1 | |
| SCHEMBL6980208 | 0.85 | CARM1 (0.43) | PRMT6CARM1PRMT3PRMT8TMEM97 | |
| Hydrochloric Acid SCHEMBL6984760 | 0.84 | DRD2 (0.40) | PRMT6CARM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6985853 | 0.84 | DRD2 (0.40) | PRMT6CARM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6979051 | 0.84 | LMNA (0.41) | SIGMAR1 | |
| SCHEMBL8578232 | 0.81 | SIGMAR1 (0.46) | CCR3SIGMAR1 | |
| SCHEMBL6983492 | 0.81 | CHRNA7 (0.40) | SIGMAR1KCNH2 | |
| Hydrochloric Acid SCHEMBL6984012 | 0.80 | SIGMAR1 (0.45) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923575-B1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-03-12 | — | — | EP | disclosed |
| US-6172085-B1 | CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-0923575-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | Takeda Chemical Industries, Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008842-A1 | CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-05 | — | — | WO | disclosed |