Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 5/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986937 | 0.91 | CTSK (0.44) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6983836 | 0.91 | CTSK (0.44) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6982381 | 0.87 | CTSK (0.43) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6986265 | 0.79 | MMP2 (0.45) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6982654 | 0.76 | MMP1 (0.52) | — | |
| SCHEMBL7084384 | 0.71 | CTSK (0.61) | CTSKCTSLCTSBCTSSCAPN1 | |
| SCHEMBL6939528 | 0.70 | MMP1 (0.47) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6939522 | 0.70 | MMP1 (0.47) | CTSKCTSLCTSBCTSS | |
| SCHEMBL7762023 | 0.70 | CTSK (0.39) | CTSKCTSLCTSBCTSS | |
| SCHEMBL7762022 | 0.70 | CTSK (0.39) | CTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |