Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 5/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983836 | 1.00 | CTSK (0.44) | CTSKMMP8MMP14MEN1LMNA | |
| SCHEMBL6981072 | 0.91 | CTSK (0.46) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6986265 | 0.87 | MMP2 (0.45) | CTSKMMP8MMP14MEN1LMNA | |
| SCHEMBL6982381 | 0.79 | CTSK (0.43) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6982654 | 0.77 | MMP1 (0.52) | MMP8MMP14MMP1MMP13 | |
| SCHEMBL6942091 | 0.72 | ADAM17 (0.46) | MMP8CTSLCTSBMMP1MMP13 | |
| SCHEMBL24252163 | 0.71 | CYP2D6 (0.46) | MMP8MMP14LMNAKMT2A | |
| SCHEMBL16156196 | 0.71 | CYP2D6 (0.46) | MMP8MMP14LMNAKMT2A | |
| SCHEMBL7946725 | 0.70 | MMP1 (0.42) | CTSKMMP8MMP14KMT2ACTSL | |
| SCHEMBL7946723 | 0.70 | MMP1 (0.42) | CTSKMMP8MMP14KMT2ACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |