Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.45 |
| ▸ | MMP3 | P08254 | 8/20 | 0.45 |
| ▸ | MMP7 | P09237 | 7/20 | 0.45 |
| ▸ | MMP1 | P03956 | 6/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.42 |
| ▸ | CTSB | P07858 | 4/20 | 0.42 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | LGMN | Q99538 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986937 | 0.87 | CTSK (0.44) | MMP1MMP8MMP13MMP14CTSK | |
| SCHEMBL6983836 | 0.87 | CTSK (0.44) | MMP1MMP8MMP13MMP14CTSK | |
| SCHEMBL6981072 | 0.79 | CTSK (0.46) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL6982381 | 0.74 | CTSK (0.43) | CTSKMEN1LMNAKMT2ACTSL | |
| SCHEMBL7556923 | 0.73 | MMP2 (0.50) | MMP2MMP3MMP7MMP1MMP8 | |
| SCHEMBL6804041 | 0.71 | MMP2 (0.49) | MMP2MMP3MMP7MMP1MMP8 | |
| SCHEMBL4431974 | 0.69 | MMP2 (0.78) | MMP2MMP3MMP7MMP1MMP8 | |
| SCHEMBL6987150 | 0.69 | ADAM17 (0.64) | MMP2MMP3MMP7MMP1MMP8 | |
| SCHEMBL6940822 | 0.68 | ADAM17 (0.56) | MMP2MMP1MMP8ADAM17MMP9 | |
| SCHEMBL16473698 | 0.68 | ATM (0.54) | CTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |