Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | REN | P00797 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986604 | 0.88 | BMP1 (0.30) | — | |
| SCHEMBL6982289 | 0.85 | MMP1 (0.37) | MMP1MMP13APPREN | |
| SCHEMBL6988232 | 0.81 | MMP1 (0.35) | MMP1MMP13APPRENMEN1 | |
| SCHEMBL6986904 | 0.81 | REN (0.36) | MMP1MMP13REN | |
| SCHEMBL6982858 | 0.80 | MMP1 (0.38) | MMP1MMP13RENLMNAFKBP1A | |
| SCHEMBL6980505 | 0.80 | MMP1 (0.36) | MMP1MMP13APPRENMEN1 | |
| SCHEMBL6981390 | 0.79 | BMP1 (0.37) | APPREN | |
| SCHEMBL7840445 | 0.79 | MMP1 (0.46) | MMP1MMP13APP | |
| SCHEMBL6942326 | 0.79 | MMP1 (0.39) | MMP1MMP13APPREN | |
| SCHEMBL6983815 | 0.78 | MMP1 (0.41) | MMP1MMP13APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |