Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodomethane SCHEMBL11687901 | 0.94 | ALDH1A1 (0.39) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL16931663 | 0.92 | ALDH1A1 (0.40) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL31111388 | 0.77 | HRH3 (0.43) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL30054008 | 0.76 | KDM4E (0.44) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL29240535 | 0.76 | — | — | |
| SCHEMBL30316733 | 0.76 | — | — | |
| SCHEMBL531613 | 0.76 | — | — | |
| SCHEMBL6488261 | 0.76 | — | — | |
| SCHEMBL9065034 | 0.75 | HRH3 (0.38) | ALDH1A1MAPTNPC1RAB9AKMT2A | |
| SCHEMBL12533533 | 0.74 | TSHR (0.43) | ALDH1A1MAPTNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174663-A1 | PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS | KING'S COLLEGE LONDON (GB) | 2024-05-30 | — | — | US | disclosed |
| CN-112300172-B | Bruton tyrosine kinase inhibitors | 比奥根MA公司 | 2024-01-16 | — | — | CN | disclosed |
| EP-4301751-A1 | PYRIMIDINE OR PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS | King's College London (GB) | 2024-01-10 | — | — | EP | disclosed |
| US-20240002415-A1 | PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2024-01-04 | — | — | US | disclosed |
| US-11780861-B2 | Phosphine reagents for azine fluoroalkylation | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2023-10-10 | — | — | US | disclosed |
| US-20220380394-A1 | PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2022-12-01 | — | — | US | disclosed |
| WO-2022185057-A1 | PYRIMIDINE OR PYRIDINE DERIVATES USEFUL AS HCN2 MODULATORS | KING'S COLLEGE LONDON (GB) | 2022-09-09 | — | — | WO | disclosed |
| WO-2022087129-A9 | PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2022-05-27 | — | — | WO | disclosed |
| CN-111526890-A | Combination therapy comprising administration of 1H-pyrazolo [4,3-B ] pyridine | H.隆德贝克有限公司 | 2020-08-11 | — | — | CN | disclosed |
| WO-2015191636-A2 | XANTHINE OXIDASE INHIBITORS AND METHODS OF USE | BAYLOR COLLEGE OF MEDICINE (US) | 2015-12-17 | — | — | WO | disclosed |
| US-5455248-A | Treatment or prevention of neurodegenerative disorders or neurotoxic injuries; binding to PCP receptors | STERLING WINTHROP INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5434159-A | Neurodegenerative disorders | STERLING WINTHROP INC. (US) | 1995-07-18 | — | — | US | disclosed |
| US-5430036-A | Neurodegenerative disorders, neurotoxic injuries | STERLING WINTHROP INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0656359-A1 | Substituted 6,11-ethano-6,11-dihydrobenzo[b]quinolizinium salts and compositionsand methods of use thereof | STERLING WINTHROP INC. (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0648769-A1 | 12-Hetero-substituted 6,11-ethano-6,11-dihydrobenzo[b] quinolizium salts and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1995-04-19 | — | — | EP | disclosed |
| US-5380729-A | Treatment or prevention of neurodegenerative disorders or neurotoxic injuries | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5196433-A | 3-SUBSTITUTED PYRIDINEMETHANOLS AND FUNGICIDES CONTAINING THEM | BASF AKTIENGESELLSCHAFT (DE) | 1993-03-23 | — | — | US | disclosed |
| EP-0525346-A1 | 3-Substituted pyridine methanols and fungicides containing them | BASF Aktiengesellschaft (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-4948912-A | HALOACETOXYALKYL ETHER | SOUTHWEST RESEARCH INSTITUTE (US) | 1990-08-14 | — | — | US | disclosed |
| US-4029800-A | 2-(4-PYRIDYL)-1,3-DIOXOLANE METHIODIDE OR 2-(1-METHYL-4-PIPERIDYL)-1,3-DIOXOLANE HYDROIODIDE | BRISTOL-MYERS COMPANY (US) | 1977-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220380394-A1 | PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION | PTPN3, PHOSPHO1, SKIC3 | ALDH1A1 4415/4885MAPT 3703/4885NPC1 3349/4885 |
| US-20240174663-A1 | PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS HCN2 MODULATORS | HCN2, HCN1, HCN3 | ALDH1A1 1933/4885MAPT 3684/4885NPC1 2150/4885 |
| US-20240002415-A1 | PHOSPHINE REAGENTS FOR AZINE FLUOROALKYLATION | PTPN3, PHOSPHO1, SKIC3 | ALDH1A1 4415/4885MAPT 3703/4885NPC1 3349/4885 |
| US-11780861-B2 | Phosphine reagents for azine fluoroalkylation | PTPN3, PHOSPHO1, SKIC3 | ALDH1A1 4415/4885MAPT 3703/4885NPC1 3349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.