SCHEMBL6982154

SCHEMBL6982154

Cc1c(C)c2c(c(C)c1N)CC(C)(CN1C(=O)c3ccccc3C1=O)O2

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.36
CYP2C9 P11712 2/20 0.36
CYP2C19 P33261 2/20 0.36
MAPT P10636 1/20 0.34
RECQL P46063 1/20 0.34
ACHE P22303 3/20 0.33
ALDH1A1 P00352 3/20 0.32
RPS6KA2 Q15349 1/20 0.32
TP53 P04637 1/20 0.32
TSHR P16473 3/20 0.31
MCOLN3 Q8TDD5 1/20 0.31
HPGD P15428 2/20 0.31
NPSR1 Q6W5P4 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MEN1 O00255 2/20 0.30
KMT2A Q03164 2/20 0.30
ALOX15 P16050 1/20 0.30
HSD17B10 Q99714 1/20 0.30
KDM4E B2RXH2 1/20 0.30
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL658096 0.86 ALDH1A1 (0.36) CYP1A2CYP2C9CYP2C19MAPTRECQL
SCHEMBL657711 0.82 MAPT (0.38) CYP1A2CYP2C9CYP2C19MAPTRECQL
SCHEMBL6981092 0.76 DRD3 (0.34) CYP2C9MAPTTP53TSHRNPSR1
Hydrochloric Acid SCHEMBL6982794 0.75 KMT2A (0.35) CYP2C9MAPTTP53TSHRNPSR1
SCHEMBL8716546 0.75 BACE1 (0.34)
SCHEMBL6985365 0.74 LMNA (0.42) ACHEALDH1A1TP53HPGDSMN1; SMN2
SCHEMBL6983488 0.74 DRD2 (0.41) CYP2C9MAPTALDH1A1TP53TSHR
Hydrochloric Acid SCHEMBL6979044 0.74 LMNA (0.41) MAPTACHEALDH1A1TP53TSHR
SCHEMBL6984897 0.74 DRD3 (0.38) MAPTMEN1KMT2AKDM4E
Hydrochloric Acid SCHEMBL8712646 0.73 ICMT (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0923575-B1 CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2003-03-12 EP disclosed
US-6172085-B1 CENTRAL NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-01-09 US disclosed