Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6983335 | 0.82 | HSD17B10 (0.38) | ALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL7831174 | 0.81 | HSD11B1 (0.36) | ALDH1A1HTTLMNAOPRM1MAPT | |
| SCHEMBL6982681 | 0.80 | THRB (0.44) | THRBTDP1ALDH1A1PDK2APEX1 | |
| SCHEMBL6971210 | 0.74 | CYP1A2 (0.41) | THRBTDP1TP53HTTLMNA | |
| SCHEMBL6982212 | 0.72 | THRB (0.46) | THRBTDP1ALDH1A1LMNAPDK2 | |
| SCHEMBL6971971 | 0.71 | NPC1 (0.44) | ALDH1A1TP53PDK2OPRM1OPRL1 | |
| SCHEMBL6633029 | 0.70 | ALDH1A1 (0.42) | ALDH1A1HCAR2TP53HTTLMNA | |
| SCHEMBL6968252 | 0.69 | MEN1 (0.42) | THRBTDP1ALDH1A1HTTLMNA | |
| SCHEMBL6978402 | 0.69 | OPRM1 (0.41) | OPRM1OPRL1OPRD1OPRK1GAA | |
| SCHEMBL6981621 | 0.67 | APEX1 (0.42) | THRBTDP1ALDH1A1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098893-B1 | CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS | MERCK PATENT GMBH (DE) | 2003-03-26 | — | — | EP | disclosed |