SCHEMBL6982070

SCHEMBL6982070

CC1(C(=O)O)OCC(c2ccccc2)(c2ccccc2)CO1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C1 Q04828 1/20 0.40
CHRNB2 P17787 1/20 0.39
SLC6A2 P23975 1/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
CHRNA4 P43681 1/20 0.39
SLC6A3 Q01959 1/20 0.39
TSHR P16473 2/20 0.39
OPRM1 P35372 2/20 0.39
OPRL1 P41146 1/20 0.39
LMNA P02545 1/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
CYP2C9 P11712 1/20 0.37
ALDH1A1 P00352 3/20 0.37
MAPT P10636 1/20 0.37
CYP1A2 P05177 2/20 0.37
HCAR3 P49019 1/20 0.37
HCAR2 Q8TDS4 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6979914 0.83 MEN1 (0.51) CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4
SCHEMBL6982212 0.81 THRB (0.46) AKR1C1LMNAMEN1KMT2AALDH1A1
SCHEMBL6981777 0.79 AKR1C1 (0.41) AKR1C1TSHROPRM1OPRL1LMNA
SCHEMBL6982378 0.77 ALDH1A1 (0.40) AKR1C1CHRNB2SLC6A2CHRNB4CHRNA3
SCHEMBL6978477 0.75 LMNA (0.39) AKR1C1CHRNB2SLC6A2CHRNB4CHRNA3
SCHEMBL6971207 0.72 OPRM1 (0.44) CHRNB2CHRNB4CHRNA3CHRNA4OPRM1
SCHEMBL6967893 0.71 CNR1 (0.40) AKR1C1KMT2AALDH1A1MAPTL3MBTL1
SCHEMBL6982594 0.71 HSD11B1 (0.39) AKR1C1CHRNB2SLC6A2CHRNB4CHRNA3
SCHEMBL15114500 0.71 FFAR3 (0.38) LMNANPSR1
SCHEMBL1818873 0.70 MAPK1 (0.41) AKR1C1CHRNB2SLC6A2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098893-B1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GMBH (DE) 2003-03-26 EP disclosed
US-6528538-B1 Reaction of 1,3-propanediol derivative with a ketone or aldehyde MERCK PATENTGESELLSCHAFT (DE) 2003-03-04 US disclosed
EP-1098893-A1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GmbH (DE) 2001-05-16 EP disclosed
WO-2000004011-A1 CYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF DYSLIPIDAEMIA, ATHEROSCLEROSIS AND DIABETES, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PROCESS MERCK PATENT GMBH (DE) 2000-01-27 WO disclosed