Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982838 | 0.93 | MMP2 (0.34) | MMP2MMP3TSHRMMP1MMP13 | |
| SCHEMBL6985386 | 0.85 | FKBP1A (0.32) | MMP2MMP3MMP1 | |
| SCHEMBL7142417 | 0.84 | MMP2 (0.36) | MMP2MMP3MMP1 | |
| SCHEMBL6980306 | 0.81 | MMP2 (0.32) | MMP2MMP3TSHRMMP1MMP13 | |
| SCHEMBL6984130 | 0.80 | HDAC3 (0.31) | — | |
| SCHEMBL6988228 | 0.78 | TGFBR1 (0.30) | — | |
| SCHEMBL6979940 | 0.75 | MMP3 (0.34) | MMP2MMP3TSHRMMP1MMP13 | |
| SCHEMBL6981500 | 0.74 | ADAM17 (0.34) | — | |
| SCHEMBL6979963 | 0.74 | PPARG (0.33) | MMP2 | |
| SCHEMBL6980808 | 0.73 | MMP3 (0.34) | MMP2MMP3TSHRMMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |