Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 5/20 | 0.32 |
| ▸ | MMP9 | P14780 | 4/20 | 0.32 |
| ▸ | MMP8 | P22894 | 4/20 | 0.32 |
| ▸ | MMP1 | P03956 | 4/20 | 0.31 |
| ▸ | MMP3 | P08254 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987034 | 0.91 | BMP1 (0.33) | FKBP1AMMP2MMP1MMP3 | |
| SCHEMBL6988468 | 0.89 | MMP2 (0.35) | FKBP1AMMP2MMP1MMP3 | |
| SCHEMBL6983239 | 0.85 | MMP2 (0.32) | MMP2MMP1MMP3 | |
| SCHEMBL6982838 | 0.85 | MMP2 (0.34) | MMP2MMP9MMP1MMP3 | |
| SCHEMBL6979849 | 0.85 | MMP2 (0.32) | FKBP1AMMP2MMP9MMP8MMP1 | |
| SCHEMBL6981500 | 0.81 | ADAM17 (0.34) | — | |
| SCHEMBL7142417 | 0.80 | MMP2 (0.36) | MMP2MMP9MMP1MMP3 | |
| SCHEMBL6988228 | 0.78 | TGFBR1 (0.30) | — | |
| SCHEMBL6980808 | 0.76 | MMP3 (0.34) | MMP2MMP9MMP8MMP1MMP3 | |
| SCHEMBL6987345 | 0.74 | MMP2 (0.35) | FKBP1AMMP2MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |