Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985009 | 0.86 | ALDH1A1 (0.38) | TSHRALDH1A1HIF1AMAPK14SMN1; SMN2 | |
| SCHEMBL6984311 | 0.82 | MAPK14 (0.44) | MAPK14ADORA2A | |
| SCHEMBL6987843 | 0.81 | HIF1A (0.43) | TSHRALDH1A1HIF1ANPSR1MAPT | |
| SCHEMBL6984146 | 0.80 | HIF1A (0.42) | TSHRALDH1A1HIF1ANPSR1MAPT | |
| SCHEMBL6989271 | 0.78 | HIF1A (0.36) | TSHRALDH1A1MPOHIF1ANPSR1 | |
| SCHEMBL6983980 | 0.78 | HIF1A (0.40) | ALDH1A1HIF1ANPSR1MAPTPPARG | |
| SCHEMBL6987183 | 0.76 | TSHR (0.45) | TSHRALDH1A1MPONPSR1SMN1; SMN2 | |
| SCHEMBL6821956 | 0.72 | ADORA1 (0.39) | TSHRALDH1A1MPOMAPTADORA2A | |
| SCHEMBL6981881 | 0.71 | PDE10A (0.43) | TSHRALDH1A1LMNAMAPK14HTT | |
| SCHEMBL6984199 | 0.70 | NPC1 (0.42) | TSHRALDH1A1MPOHIF1ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |