Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986812 | 0.74 | ALDH1A1 (0.40) | NPC1RAB9APAX8ALDH1A1PTGS1 | |
| SCHEMBL6987843 | 0.73 | HIF1A (0.43) | NPC1RAB9APAX8ALDH1A1PTGS2 | |
| SCHEMBL6984146 | 0.72 | HIF1A (0.42) | NPC1RAB9APAX8ALDH1A1HTT | |
| SCHEMBL6989271 | 0.71 | HIF1A (0.36) | MPOALDH1A1LMNAHTTHIF1A | |
| SCHEMBL6983980 | 0.71 | HIF1A (0.40) | NPC1RAB9APAX8ALDH1A1HTT | |
| SCHEMBL6984135 | 0.70 | TSHR (0.39) | RAB9AMPOALDH1A1LMNAHTT | |
| SCHEMBL6981881 | 0.70 | PDE10A (0.43) | ALDH1A1LMNAHTTTSHRGAA | |
| SCHEMBL6818684 | 0.69 | ADORA1 (0.35) | ALDH1A1PTGS1PTGS2KMT2ASMN1; SMN2 | |
| SCHEMBL6986371 | 0.68 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1HTTKMT2A | |
| SCHEMBL6987355 | 0.68 | ALDH1A1 (0.38) | NPC1RAB9AALDH1A1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |