Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987568 | 0.82 | BMPR1B (0.35) | POLBGAALMNANR3C2CYP2C8 | |
| SCHEMBL6988697 | 0.80 | NR3C2 (0.43) | PDE10AMAPK14NR3C2TP53 | |
| SCHEMBL7367730 | 0.80 | NPBWR1 (0.39) | — | |
| SCHEMBL6987355 | 0.79 | ALDH1A1 (0.38) | ALDH1A1MDM2GAATSHRTP53 | |
| SCHEMBL6986371 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MDM2POLBGAAHTT | |
| SCHEMBL7371162 | 0.78 | PDE10A (0.43) | PDE10AALDH1A1MDM2POLBADORA2B | |
| SCHEMBL6987522 | 0.78 | KMT2A (0.38) | ALDH1A1POLBLMNA | |
| SCHEMBL6986812 | 0.77 | ALDH1A1 (0.40) | ALDH1A1MDM2GAALMNAHTT | |
| SCHEMBL6987843 | 0.76 | HIF1A (0.43) | ALDH1A1POLBGAALMNAHTT | |
| SCHEMBL7369460 | 0.76 | ADORA2B (0.47) | PDE10AALDH1A1ADORA2BHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |