Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987843 | 0.86 | HIF1A (0.43) | HIF1AALDH1A1GAAPPARGNCOA2 | |
| SCHEMBL6983980 | 0.83 | HIF1A (0.40) | HIF1AALDH1A1GAAPPARGNCOA2 | |
| SCHEMBL6984135 | 0.80 | TSHR (0.39) | HIF1AALDH1A1PPARGNCOA2NCOA1 | |
| SCHEMBL6989271 | 0.78 | HIF1A (0.36) | HIF1AALDH1A1GAAPPARGNCOA2 | |
| SCHEMBL6985009 | 0.76 | ALDH1A1 (0.38) | HIF1AALDH1A1TSHRHTTSMN1; SMN2 | |
| SCHEMBL6986371 | 0.76 | ALDH1A1 (0.41) | ALDH1A1GAAKMT2ATSHRTP53 | |
| SCHEMBL6981881 | 0.75 | PDE10A (0.43) | ALDH1A1GAATSHRTP53POLB | |
| SCHEMBL6984199 | 0.72 | NPC1 (0.42) | HIF1AALDH1A1GAAKMT2ATSHR | |
| SCHEMBL6984311 | 0.72 | MAPK14 (0.44) | POLB | |
| SCHEMBL6987355 | 0.71 | ALDH1A1 (0.38) | ALDH1A1GAAKMT2ATSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313733-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002018382-A1 | PYRAZOLOPYRIDINE COMPOUND AND PHARMACEUTICAL USE THEREOF | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-07 | — | — | WO | disclosed |