Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8801366 | 0.87 | CA2 (0.52) | CA2MTNR1AMTNR1BKDM4EGLA | |
| SCHEMBL6989977 | 0.83 | CYP1A2 (0.50) | CA2MTNR1AMTNR1BPDGFRBPDGFRA | |
| SCHEMBL6989136 | 0.78 | DAO (0.49) | KDM4CALOX15 | |
| SCHEMBL7491861 | 0.78 | MAPT (0.45) | KDM4EKDM4CALOX15CHEK2SMN1; SMN2 | |
| SCHEMBL11410994 | 0.76 | KMT2A (0.55) | SMN1; SMN2MAOAMAOB | |
| SCHEMBL4737672 | 0.73 | HDAC8 (0.47) | KDM4CALOX15CHEK2 | |
| SCHEMBL6993755 | 0.72 | LOXL2 (0.60) | MTNR1AMTNR1BKDM4EPDGFRBPDGFRA | |
| SCHEMBL22815757 | 0.71 | CA12 (0.54) | CA2KDM4EGLAGAAFLT3 | |
| SCHEMBL7490718 | 0.70 | IMPDH2 (0.48) | CA2KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6619148 | 0.70 | PCSK9 (0.57) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |