Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 3/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | F11 | P03951 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6992345 | 0.90 | SIGMAR1 (0.46) | DAOLOXL2PCSK9ALOX15RHEB | |
| SCHEMBL6993860 | 0.87 | DAO (0.44) | DAOLOXL2PCSK9ALOX15DRD3 | |
| SCHEMBL6826452 | 0.86 | LOXL2 (0.64) | DAOLOXL2PCSK9RHEBF11 | |
| SCHEMBL6619148 | 0.84 | PCSK9 (0.57) | DAOLOXL2PCSK9AHR | |
| SCHEMBL7500914 | 0.83 | DRD4 (0.44) | DAORHEBDRD3SIGMAR1DRD4 | |
| SCHEMBL6989977 | 0.83 | CYP1A2 (0.50) | LOXL2ALOX15AHR | |
| SCHEMBL4737672 | 0.79 | HDAC8 (0.47) | ALOX15KDM4C | |
| SCHEMBL613213 | 0.78 | RHEB (0.52) | DAOLOXL2ALOX15RHEBF11 | |
| SCHEMBL13624442 | 0.78 | ALOX15 (0.50) | DAOLOXL2PCSK9ALOX15F11 | |
| SCHEMBL7490718 | 0.78 | IMPDH2 (0.48) | DAOLOXL2RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322646-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002008225-A1 | 2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2002-01-31 | — | — | WO | disclosed |