SCHEMBL6984429

SCHEMBL6984429

Cc1cc(N2CCC=C(c3ccccc3)C2)nc(Nc2ccc(C(C)C)cc2Br)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
MAPT P10636 2/20 0.39
CRHR1 P34998 5/20 0.38
HTT P42858 2/20 0.36
TSHR P16473 2/20 0.36
PKM P14618 1/20 0.36
CRHBP P24387 1/20 0.36
PIK3CB P42338 1/20 0.36
CRHR2 Q13324 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C19 P33261 1/20 0.35
POLB P06746 1/20 0.35
LMNA P02545 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
SLC2A1 P11166 1/20 0.34
KDM4E B2RXH2 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6981234 0.86 CRHR1 (0.40) ALDH1A1MAPTCRHR1HTTTSHR
SCHEMBL27475432 0.82 SLC2A1 (0.39) ALDH1A1MAPTHTTTSHRPKM
SCHEMBL7680672 0.80 CRHR1 (0.57) ALDH1A1MAPTCRHR1HTTTSHR
Hydrochloric Acid SCHEMBL6985578 0.77 CRHR1 (0.67) CRHR1
SCHEMBL7678043 0.74 MAPT (0.59) ALDH1A1MAPTCRHR1MEN1KMT2A
SCHEMBL6980587 0.71 LMNA (0.44) ALDH1A1MAPTHTTTSHRPKM
Hydrochloric Acid SCHEMBL27546093 0.69 CRHR1 (0.45) CRHR1
SCHEMBL27472886 0.68 SLC2A1 (0.40) ALDH1A1MAPTHTTTSHRPKM
SCHEMBL7680556 0.65 MAPT (0.43) ALDH1A1MAPTCRHR1PKMPIK3CB
SCHEMBL8208478 0.65 CRHR1 (0.54) ALDH1A1MAPTCRHR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0976745-B1 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES TAISHO PHARMACEUTICAL CO LTD (JP) 2003-08-13 EP disclosed
US-6187781-B1 CORTICOTROPIN RELEASING FACTOR RECEPTOR ANTAGONISTS; ALZHEIMER*S, HUNTINGTON, AND PARKINSON DISEASE; ANTIDEPRESSANTS, ANXIOLYTIC AGENTS TAISHO PHARMACEUTICAL CO., LTD. (JP) 2001-02-13 US disclosed
EP-0976745-A1 4-TETRAHYDROPYRIDYLPYRIMIDINE DERIVATIVES TAISHO PHARMACEUTICAL CO., LTD (JP) 2000-02-02 EP disclosed