Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7680556 | 0.85 | MAPT (0.43) | MAPTALDH1A1KMT2ACRHR1LMNA | |
| SCHEMBL8208478 | 0.85 | CRHR1 (0.54) | MAPTALDH1A1MEN1KMT2ACRHR1 | |
| SCHEMBL7683030 | 0.84 | ALDH1A1 (0.41) | MAPTALDH1A1CRHR1LMNATP53 | |
| SCHEMBL21004329 | 0.84 | ALDH1A1 (0.46) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7676334 | 0.84 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7681125 | 0.82 | MAPT (0.44) | MAPTALDH1A1MEN1KMT2ACRHR1 | |
| SCHEMBL7682784 | 0.82 | ALDH1A1 (0.41) | MAPTALDH1A1MEN1KMT2ACRHR1 | |
| SCHEMBL7680672 | 0.81 | CRHR1 (0.57) | MAPTALDH1A1KMT2ACRHR1LMNA | |
| SCHEMBL7684971 | 0.80 | MAPT (0.67) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL7687760 | 0.79 | NPC1 (0.39) | MAPTALDH1A1MEN1KMT2ACRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6342503-B1 | ANTIDEPRESSANTS, EATING DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2002-01-29 | — | — | US | disclosed |
| US-6107301-A | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| CN-1142817-A | 1N-alkyl-N-arylpyrimidinamines and derivatives thereof | DU PONT MERCK PHARMA (US) | 1997-02-12 | — | — | CN | disclosed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010506-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-20 | — | — | WO | disclosed |